Cognitive Function

Theracurmin Supplementation May be a Therapeutic Option for Older Patients with Alzheimer’s Disease: A 6-Month Retrospective Follow-Up Study.

Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR.

Schizophrenia Res. 2018 May; 195: 572–573.

Cognitive Function

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.

Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J,Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR.  

Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277.

Cognitive Function

The Effect of Theracurmin on Cognitive Function in an Older Patient with Chemobrain.

Erken N, Dost Gunay FS, Soysal P, Isik AT.

Clin Interv Aging. 2020 May 19;15:691-693. doi: 10.2147/CIA.S252229. eCollection 2020.

Schizophrenia

The effects of curcumin on Brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study.

Dost FS, Kaya D, Ontan MS, Erken N, Bulut EA, Aydin AE, Isik AT.

Curr Alzheimer Res. 2021 Dec; 18 (14): 1087-1092. doi: 10.2174/1567205019666211221125255.

Migraine

The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients.

Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR, Esdighiyan M, Djalali M, Honarvar NM, Djalali M.

Immunogenetics. 2017 Jun; 69 (6): 371-378

Pancreatic Cancer/ Biliary Tract Cancer

A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.

Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.

Cancer Chemother Pharmacol. 2013 Jun; 71 (6): 1521-1530.

Esophageal Adenocarcinoma

Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response.

Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK.

Front Oncol. 2013 May 29; 3: 137.

Prostate & Bladder Cancer

Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest.

Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS.

Oncol Rep. 2016 Mar; 35 (3): 1463-1472. doi org/10.3892/or.2015.4537.

Respiratory System

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.

Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T.

Int J Chron Obstruct Pulmon Dis. 2016 Aug 26; 11: 2029-2034.

Respiratory Health

Clinically Proven for Upper Respiratoty Health

According to the Journal of Dietary Supplements, Theracurmin Super* "is the first o obtain evidence using a randomized controlled trial to demonstrate curcumin's efficacy in [providing support against upper respiratory iritations] in healthy humans", showing beneficial effects on coughing, sneezing, runny nose, and stuffy nose with no reported side effects. 

Kuwabara Y, et al. J Diet Suppl. 2023 Mar; (16 1-28

Sneezing: 57% less sneezing, reduction of days from 18.4 days to 7.9 days 

Nasal Discharge: 60% less nasal discharge, reduction of days from 24.4 days to 9.8 days 

Blocked Nose: 79% less blocked nose, reduction of days from 14.2 days to 3.0 days 

Cough: 71% less coughing, reduction of days from 9.0 days to 2.6 days

Liver Function

Effects of Theracurmin® consumption on liver function, fatigue, and sleep: a randomized, double-blind, placebo-controlled, parallel-comparison study.

Kuwabara Y, Hirose A, Lee HJ, Hashimoto D, Iio SI, and Takara T.

Functional Food in Health and Disease 2021 11; (6): 246-269.

Hangover

Effects of a Health Drink Containing the Extract of the Hovenia Dulcis Fruit Stalk andTheracurmin, on Ethanol-Induced Hangover.

Kang NE, Oh YS, Yeo HK, Baik HW, Jang SE.

The Korean Society of Food culture. 2021; 36 (6): 1-8.

Muscle Recovery

Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.

Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K.

Eur J Appl Physiol. 2015 Sep; 115 (9): 1949-1957. doi 10.1007/s00421-015-3170-4

Muscle Recovery

Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men.

Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H.

J Nutr Sci Vitaminol (Tokyo). 2019; 65 (1): 82-89. doi 10.3177/jnsv.65.82.

Muscle Recovery

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation.

Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H.

Scand J Med Sci Sports. 2019 Apr; 29 (4): 524-534. doi 10.1111/sms.13373.

Osteoarthritis

Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study.

Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T.

J Orthop Sci. 2014 Nov; 19 (6): 933-939.

Osteoarthritis

The Oral Administration of Highly-Bioavailable Curcumin for One Year Has Clinical and Chondro-Protective Effects: A Randomized, Double-Blinded, Placebo-Controlled Prospective Study.

Nakagawa Y, Mori K, Yamada S, Mukai S, Hirose A, Nakamura R.

Arthrosc Sports Med Rehabil. 2022 Apr; 4 (2): 393-342. doi: 10.1016/j.asmr.2021.10.016

Osteoarthritis

Short-term Effectiveness of Nexala® in the Treatment of Patients with Gonarthrosis and Coxarthrosis.

Pablo M, Nestor Z, Jorge L.

Jpn Pharmacol Ther 2021 49; (2): 229–238.

Osteoarthritis

The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study.

Nakagawa Y, Mukai S, Yamada S, Murata S, Yabumoto H, Maeda T, Akamatsu S.

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 2020 13: 1–8.doi: 10.1177/1179544120948471.

Osteoarthritis

Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis.

Shin YA, Suk MH, Jang HS, Choi HJ.

J Exerc Rehabil. 2017 Dec; 13 (6): 684-692.

Vascular Endothelial Function

Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.

Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.

Nutr Res. 2012 Oct; 32 (10): 795-799.

Endothelial Function

Curcumin supplementation attenuates the decrease in endothelial function following eccentric exercise.

Choi Y, Tanabe Y, Akazawa N, Miyaki A, Maeda S.

J Exerc Nutrition Biochem. 2019 Jun 30; 23 (2):7-12. doi 10.20463/jenb.2019.0010.

Central Arterial Hemodynamics

Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study.

Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S.

Am J Hypertens. 2012 Jun; 25 (6): 651-656.

Cardiovascular System

Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women.

Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.

Artery Res. 2013 Mar; 7 (1): 67-72

Crohn’s Disease

Highly Bioavailable Curcumin Derivative Ameliorates Crohn’s Disease Symptoms: A Randomized, Double-Blind, Multicenter Study.

Sugimoto K, Ikeya K, Bamba S, Andoh A, Yamasaki H, Mitsuyama K, Nasuno M, Tanaka H, Matsuura A, Kato M, Ishida N, Tamura S, Takano R, Tani S, Osawa S, Nishihira J, Hanai H.

J Crohns Colitis.2020 May 15. doi: 10.1093/ecco-jcc/jjaa097. Online ahead of print.

Hangover

Effects of a Health Drink Containing the Extract of the Hovenia Dulcis Fruit Stalk andTheracurmin, on Ethanol-Induced Hangover.

Kang NE, Oh YS, Yeo HK, Baik HW, Jang SE.

The Korean Society of Food culture. 2021; 36 (6): 1-8.

Joint Health

Many middle aged and older adults are affected by joint discomfort as issues become more prominent with age. Discomfort in joints, specifically in the knee, can decrease quality of life and inhibit daily activities. 

To explore natural options to support joint health, Theracurmin, a highly bioavailable curcumin, was administered twice a day to 50 patients. By the end of the trial period, Theracurmin significantly reduced knee discomfort in patients.

Nakawa Y, et al. J Orthop Sci. 2014 Nov; 19 (6): 933-939

Bioavailability

Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects.

Chung H, Yoon SH, Cho JY, Yeo HK, Shin D, Park JY.

International Journal of Clinical Pharmacology and Therapeutics. 2021 Oct; 59(10): 684-690.

Bioavailability

Drinkable preparation of Theracurmin exhibits high absorption efficiency–a single-dose, double-blind, 4-way crossover study.

Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada T, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K.

Biol Pharm Bull. 2013; 36 (11): 1708-1714.

Bioavailability

Innovative preparation of curcumin for improved oral bioavailability.

Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T.

Biol Pharm Bull. 2011; 34 (5): 660-665.

Bioavailability

Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study.

Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR.

Schizophrenia Res. 2018 May; 195: 572–573

Tolerability

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.

Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T.

Cancer Chemother Pharmacol. 2012 Jan; 69 (1): 65-70.

Tolerability

Safety Evaluation of Theracurmin® in Healthy Japanese Adults. ―A Randomized, Double-blind, Placebo-controlled Parallel-group Study―

Takahashi T, Iio S, Takara T.

Jpn Pharmacol Thervol. 2019 Jul 1; 47(7): 1097-1113